It was Paul’s gateway into Italy on his journey to Rome (Acts 28:13).
The coins of Rhegium showed the gods Castor and Polux, the twin sons of Zeus, who were also the figureheads on the Alexandrian ship in which Paul was sailing to Puteoli (Acts 28:11-13)
Rome was supposedly established by Romulus and Rhemus the sons of Mars.
The end of Acts deals with Paul’s imprisonment in Rome. He had some privelege and liberty, and many opportunities to teach there, thus achieving one of his ambitions (Acts 19:21, 23:11, Rom 1:14-15).
Onesiphorus helped Paul in Rome (2Tm 1:16-18).
Aquila and Priscilla worked in Rome until expelled by government edict (Acts 18:2).
People from Rome were in Jerusalem on the day of Pentecost (Acts 2:9-11).